Integrated research on Developmental determinants of Ageing and Longevity


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posted on 2014/09

Dlx genes and the maintenance of bone homeostasis and skeletal integrity

Levi,G., Gitton,Y.

Cell Death.Differ. 2014/09, Volume 21, Number 9, 1345-1346

posted on 2014/08/15

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen,J., Beekman,M., Uh,H.W., Broer,L., Ayers,K.L., Tan,Q., Kamatani,Y., Bennet,A.M., Tamm,R., Trompet,S., Guethbjartsson,D.F., Flachsbart,F., Rose,G., Viktorin,A., Fischer,K., Nygaard,M., Cordell,H.J., Crocco,P., van den Akker,E.B., Böhringer,S., Helmer,Q., Nelson,C.P., Saunders,G.I., Alver,M., Andersen-Ranberg,K., Breen,M.E., van der Breggen,R., Caliebe,A., Capri,M., Cevenini,E., Collerton,J.C., Dato,S., Davies,K., Ford,I., Gampe,J., Garagnani,P., de Geus,E.J., Harrow,J., van Heemst,D., Heijmans,B.T., Heinsen,F.A., Hottenga,J.J., Hofman,A., Jeune,B., Jonsson,P.V., Lathrop,M., Lechner,D., Martin-Ruiz,C., Mcnerlan,S.E., Mihailov,E., Montesanto,A., Mooijaart,S.P., Murphy,A., Nohr,E.A., Paternoster,L., Postmus,I., Rivadeneira,F., Ross,O.A., Salvioli,S., Sattar,N., Schreiber,S., Stefansson,H., Stott,D.J., Tiemeier,H., Uitterlinden,A.G., Westendorp,R.G., Willemsen,G., Samani,N.J., Galan,P., Sorensen,T.I., Boomsma,D.I., Jukema,J.W., Rea,I.M., Passarino,G., de Craen,A.J., Christensen,K., Nebel,A., Stefansson,K., Metspalu,A., Magnusson,P., Blanche,H., Christiansen,L., Kirkwood,T.B., van Duijn,C.M., Franceschi,C., Houwing-Duistermaat,J.J., Slagboom,P.E.

Hum.Mol.Genet. 2014/08/15, Volume 23, Number 16, 4420-4432

posted on 2014/08

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility

Guigas,B., de Leeuw van Weenen, J.E., van Leeuwen,N., Simonis-Bik,A.M., van Haeften,T.W., Nijpels,G., Houwing-Duistermaat,J.J., Beekman,M., Deelen,J., Havekes,L.M., Penninx,B.W., Vogelzangs,N., van 't,Riet E., Dehghan,A., Hofman,A., Witteman,J.C., Uitterlinden,A.G., Grarup,N., Jorgensen,T., Witte,D.R., Lauritzen,T., Hansen,T., Pedersen,O., Hottenga,J., Romijn,J.A., Diamant,M., Kramer,M.H., Heine,R.J., Willemsen,G., Dekker,J.M., Eekhoff,E.M., Pijl,H., de Geus,E.J., Slagboom,P.E., 't Hart,L.M.

Diabet.Med. 2014/08, Volume 31, Number 8, 1001-1008

posted on 2014/08

Single and combined effects of prenatal immune activation and peripubertal stress on parvalbumin and reelin expression in the hippocampal formation

Giovanoli,S., Weber,L., Meyer,U.

Brain Behav.Immun. 2014/08, Volume 40, Number , 48-54

posted on 2014/08

Whole-genome sequence variation, population structure and demographic history of the Dutch population

Nat.Genet. 2014/08, Volume 46, Number 8, 818-825

posted on 2014/08

DNA methylation, ageing and the influence of early life nutrition

Lillycrop,K.A., Hoile,S.P., Grenfell,L., Burdge,G.C.

Proc.Nutr.Soc. 2014/08, Volume 73, Number 3, 413-421

posted on 2014/08

mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies

Sevini,F., Giuliani,C., Vianello,D., Giampieri,E., Santoro,A., Biondi,F., Garagnani,P., Passarino,G., Luiselli,D., Capri,M., Franceschi,C., Salvioli,S.

Exp.Gerontol. 2014/08, Volume 56, Number , 234-244

posted on 2014/07/05

Does autophagy mediate age-dependent effect of dietary restriction responses in the filamentous fungus Podospora anserina?

van Diepeningen,A.D., Engelmoer,D.J., Sellem,C.H., Huberts,D.H., Slakhorst,S.M., Sainsard-Chanet,A., Zwaan,B.J., Hoekstra,R.F., Debets,A.J.

Philos.Trans.R.Soc.Lond B Biol.Sci. 2014/07/05, Volume 369, Number 1646, 20130447

posted on 2014/07/03

Attenuated sensing of SHH by Ptch1 underlies evolution of bovine limbs

Lopez-Rios,J., Duchesne,A., Speziale,D., Andrey,G., Peterson,K.A., Germann,P., Unal,E., Liu,J., Floriot,S., Barbey,S., Gallard,Y., Muller-Gerbl,M., Courtney,A.D., Klopp,C., Rodriguez,S., Ivanek,R., Beisel,C., Wicking,C., Iber,D., Robert,B., McMahon,A.P., Duboule,D., Zeller,R.

Nature 2014/07/03, Volume 511, Number 7507, 46-51

posted on 2014/07

On the fate of seasonally plastic traits in a rainforest butterfly under relaxed selection

Oostra,V., Brakefield,P.M., Hiltemann,Y., Zwaan,B.J., Brattstrom,O.

Ecol.Evol. 2014/07, Volume 4, Number 13, 2654-2667


IDEAL dissertations

Lovisa Högberg (5th of October 2012) Prenatal influences on health outcomes over the lifespan: Effects of smoking, socio-economic status and foetal growth. Karolinska Insititute

Vicencio Oostra (26th of June 2013) Hormonal and transcriptional mechanisms underlying developmental plasticity of life histories in a seasonal butterfly. Leiden University

Oluwatosin O. Taiwo (2013) The Role of DNA Methylation in Stem Cell Ageing. University college London

Alexis Grimaldi (16th of May 2014) Crosstalk between thyroid hormones and glucocrticoids during Xenopus tropicalis metamorphosis. Le Centre national de la recherche scientifique

Joris Deelen (25th of June 2014) Genetic and biomarker studies of human longevity. Leiden University Medical Center

Marianne Nygaard (8th of July 2014) Genetic Determinants of Healthy Aging – Studies of genetic variation associated with human longevity . Southern Denmark University

Joost van de Heuvel (25th of November 2014) The evolution and plasticity of life histories upon variation in nutrition : an ageing focused integrative approach. Leiden University

Erik B. van den Akker (18th of February 2015) Computational biology in human aging. An omics data integration approach. Leiden University Medical Center

Linda Ahrenfeldt (15th of Oktober 2015) Opposite-sex vs same-sex twins: mortality, cancer and behavior. Southern Denmark University

Fenni Rusli (29th of August 2016) Diet-induced phenotypic plasticity during aging. Wageningen University.  

Book Publications

Non-Genetic Inheritance. Tobias Uller and Heikki Helanterä. Volume 1, September 2013, Pages 27-32, ISSN (Online) 2084-8846, DOI:10.2478/ng-2013-0003.

Immunosenescence: Psychosocial and Behavioral Determinants. Jos A. Bosch, Anna C. Phillips, Anna C., Janet Lord (Eds.) 2013. Gramham Pawelec and Ludmilla Müller. Introduction to Ageing of the Adaptive Immune System. Chapter 2, pp 17-32.  DOI: 10.1007/978-1-4614-4776-4_2

The Philosophy of Biology: A companion for Educators. K.Kampouakis (ed.) History, Philosophy and Theory of the Life Sciences; Volume 1, 2013. Tobias Uller. Non-Genetic Inheritance and Evolution, pp 267-287.  DOI: 10.1007/978-94-007-6537-5_14.


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