Integrated research on Developmental determinants of Ageing and Longevity

Publications

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posted on 2013

Genetics of longevity in model organisms: debates and paradigm shifts

Gems,D., Partridge,L.

Annu.Rev.Physiol 2013, Volume 75, Number , 621-644

posted on 2013

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

Slieker,R.C., Bos,S.D., Goeman,J.J., Bovee,J.V., Talens,R.P., van der Breggen,R., Suchiman,H.E., Lameijer,E.W., Putter,H., van den Akker,E.B., Zhang,Y., Jukema,J.W., Slagboom,P.E., Meulenbelt,I., Heijmans,B.T.

Epigenetics.Chromatin. 2013, Volume 6, Number 1, 26-

posted on 2013

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

Porcu,E., Medici,M., Pistis,G., Volpato,C.B., Wilson,S.G., Cappola,A.R., Bos,S.D., Deelen,J., den Heijer,M., Freathy,R.M., Lahti,J., Liu,C., Lopez,L.M., Nolte,I.M., O'Connell,J.R., Tanaka,T., Trompet,S., Arnold,A., Bandinelli,S., Beekman,M., Böhringer,S., Brown,S.J., Buckley,B.M., Camaschella,C., de Craen,A.J., Davies,G., de Visser,M.C., Ford,I., Forsen,T., Frayling,T.M., Fugazzola,L., Gogele,M., Hattersley,A.T., Hermus,A.R., Hofman,A., Houwing-Duistermaat,J.J., Jensen,R.A., Kajantie,E., Kloppenburg,M., Lim,E.M., Masciullo,C., Mariotti,S., Minelli,C., Mitchell,B.D., Nagaraja,R., Netea-Maier,R.T., Palotie,A., Persani,L., Piras,M.G., Psaty,B.M., Raikkonen,K., Richards,J.B., Rivadeneira,F., Sala,C., Sabra,M.M., Sattar,N., Shields,B.M., Soranzo,N., Starr,J.M., Stott,D.J., Sweep,F.C., Usala,G., van der Klauw,M.M., van Heemst,D., van Mullem,A., Vermeulen,S.H., Visser,W.E., Walsh,J.P., Westendorp,R.G., Widen,E., Zhai,G., Cucca,F., Deary,I.J., Eriksson,J.G., Ferrucci,L., Fox,C.S., Jukema,J.W., Kiemeney,L.A., Pramstaller,P.P., Schlessinger,D., Shuldiner,A.R., Slagboom,E.P., Uitterlinden,A.G., Vaidya,B., Visser,T.J., Wolffenbuttel,B.H., Meulenbelt,I., Rotter,J.I., Spector,T.D., Hicks,A.A., Toniolo,D., Sanna,S., Peeters,R.P., Naitza,S.

PLoS.Genet. 2013, Volume 9, Number 2, e1003266-

posted on 2013

GREM1, FRZB and DKK1 mRNA levels correlate with osteoarthritis and are regulated by osteoarthritis-associated factors

Leijten,J.C., Bos,S.D., Landman,E.B., Georgi,N., Jahr,H., Meulenbelt,I., Post,J.N., van Blitterswijk,C.A., Karperien,M.

Arthritis Res.Ther. 2013, Volume 15, Number 5, R126-

posted on 2012/12

Methylation of ELOVL2 gene as a new epigenetic marker of age

Garagnani,P., Bacalini,M.G., Pirazzini,C., Gori,D., Giuliani,C., Mari,D., Di Blasio,A.M., Gentilini,D., Vitale,G., Collino,S., Rezzi,S., Castellani,G., Capri,M., Salvioli,S., Franceschi,C.

Aging Cell 2012/12, Volume 11, Number 6, 1132-1134

posted on 2012/11

Bitter taste receptor polymorphisms and human aging

Campa,D., De Rango,F., Carrai,M., Crocco,P., Montesanto,A., Canzian,F., Rose,G., Rizzato,C., Passarino,G., Barale,R.

PLoS.One. 2012/11, Volume 7, Number 11, e45232

posted on 2012/10

From infancy to pregnancy: birth weight, body mass index, and the risk of gestational diabetes

Lagerros,Y.T., Cnattingius,S., Granath,F., Hanson,U., Wikstrom,A.K.

Eur.J.Epidemiol. 2012/10, Volume 27, Number 10, 799-805

posted on 2012/10

High birth weight and obesity--a vicious circle across generations

Cnattingius,S., Villamor,E., Lagerros,Y.T., Wikstrom,A.K., Granath,F.

Int.J.Obes.(Lond) 2012/10, Volume 36, Number 10, 1320-1324

posted on 2012/09/01

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

Zeggini,E., Panoutsopoulou,K., Southam,L., Day-Williams,A.G., Lopes,M.C., Boraska,V., Beazley,C., Blackburn,H., Bumpstead,S., Hunt,S.E., Potter,S.C., Shin,S.Y., Yadav,V.K., Deloukas,P., Rayner,N.W., Lopes,M., Elliott,K.S., Esko,T., Metspalu,A., Evangelou,E., Ioannidis,J.P., Hofman,A., Kerkhof,H.J., RivadeneAUa,F., Uitterlinden,A.G., van Meurs,J.B., Houwing-Duistermaat,J.J., Kloppenburg,M., Bos,S.D., Slagboom,P.E., Meulenbelt,I., Ingvarsson,T., Jonsdottir,I., Jonsson,H., Stefansson,K., Thorleifsson,G., Styrkarsdottir,U., Mangino,M., Metrustry,S., Zhai,G., O'Neill,F., Valdes,A.M., Spector,T.D., Raine,E.V., Ratnayake,M., BAUrell,F., McCaskie,A., Loughlin,J., Ricketts,M., Koller,N.C., Salter,D., Ralston,S.H., Sherburn,K., Dixon,K., Ollier,W.E., Arden,E., Battley,P.K., Aslam,N., Joseph,J., Rai,A., Carluke,I., Reed,M.R., Walker,K., Doherty,S., Wheeler,M., Doherty,M., Gordon,A., Paling,E., Swift,D., Wilkinson,J.M., Keen,R., Mitchell,S., Watkins,B., Chapman,K., Arden,N., Carr,A., Ioannidis,P.A., Wallis,G.A.

Lancet 2012/09/01, Volume 380, Number 9844, 815-823

posted on 2012/08

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs2

Talens,R.P., Christensen,K., Putter,H., Willemsen,G., Christiansen,L., Kremer,D., Suchiman,H.E., Slagboom,P.E., Boomsma,D.I., Heijmans,B.T.

Aging Cell 2012/08, Volume 11, Number 4, 694-703

 

IDEAL dissertations

Lovisa Högberg (5th of October 2012) Prenatal influences on health outcomes over the lifespan: Effects of smoking, socio-economic status and foetal growth. Karolinska Insititute

Vicencio Oostra (26th of June 2013) Hormonal and transcriptional mechanisms underlying developmental plasticity of life histories in a seasonal butterfly. Leiden University

Oluwatosin O. Taiwo (2013) The Role of DNA Methylation in Stem Cell Ageing. University college London

Alexis Grimaldi (16th of May 2014) Crosstalk between thyroid hormones and glucocrticoids during Xenopus tropicalis metamorphosis. Le Centre national de la recherche scientifique

Joris Deelen (25th of June 2014) Genetic and biomarker studies of human longevity. Leiden University Medical Center

Marianne Nygaard (8th of July 2014) Genetic Determinants of Healthy Aging – Studies of genetic variation associated with human longevity . Southern Denmark University

Joost van de Heuvel (25th of November 2014) The evolution and plasticity of life histories upon variation in nutrition : an ageing focused integrative approach. Leiden University

Erik B. van den Akker (18th of February 2015) Computational biology in human aging. An omics data integration approach. Leiden University Medical Center

Linda Ahrenfeldt (15th of Oktober 2015) Opposite-sex vs same-sex twins: mortality, cancer and behavior. Southern Denmark University

Fenni Rusli (29th of August 2016) Diet-induced phenotypic plasticity during aging. Wageningen University.  

Book Publications

Non-Genetic Inheritance. Tobias Uller and Heikki Helanterä. Volume 1, September 2013, Pages 27-32, ISSN (Online) 2084-8846, DOI:10.2478/ng-2013-0003.

Immunosenescence: Psychosocial and Behavioral Determinants. Jos A. Bosch, Anna C. Phillips, Anna C., Janet Lord (Eds.) 2013. Gramham Pawelec and Ludmilla Müller. Introduction to Ageing of the Adaptive Immune System. Chapter 2, pp 17-32.  DOI: 10.1007/978-1-4614-4776-4_2

The Philosophy of Biology: A companion for Educators. K.Kampouakis (ed.) History, Philosophy and Theory of the Life Sciences; Volume 1, 2013. Tobias Uller. Non-Genetic Inheritance and Evolution, pp 267-287.  DOI: 10.1007/978-94-007-6537-5_14.

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