Integrated research on Developmental determinants of Ageing and Longevity


or filter by or
posted on 2013/03

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

Peters,M.J., Broer,L., Willemen,H.L., Eiriksdottir,G., Hocking,L.J., Holliday,K.L., Horan,M.A., Meulenbelt,I., Neogi,T., Popham,M., Schmidt,C.O., Soni,A., Valdes,A.M., Amin,N., Dennison,E.M., Eijkelkamp,N., Harris,T.B., Hart,D.J., Hofman,A., Huygen,F.J., Jameson,K.A., Jones,G.T., Launer,L.J., Kerkhof,H.J., de Kruijf,M., McBeth,J., Kloppenburg,M., Ollier,W.E., Oostra,B., Payton,A., Rivadeneira,F., Smith,B.H., Smith,A.V., Stolk,L., Teumer,A., Thomson,W., Uitterlinden,A.G., Wang,K., van Wingerden,S.H., Arden,N.K., Cooper,C., Felson,D., Gudnason,V., Macfarlane,G.J., Pendleton,N., Slagboom,P.E., Spector,T.D., Volzke,H., Kavelaars,A., van Duijn,C.M., Williams,F.M., van Meurs,J.B.

Ann.Rheum.Dis. 2013/03, Volume 72, Number 3, 427-436

posted on 2013/03

Priming of metabolic dysfunctions by prenatal immune activation in mice: relevance to schizophrenia

Pacheco-Lopez,G., Giovanoli,S., Langhans,W., Meyer,U.

Schizophr.Bull. 2013/03, Volume 39, Number 2, 319-329

posted on 2013/03

Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism

Collino,S., Montoliu,I., Martin,F.P., Scherer,M., Mari,D., Salvioli,S., Bucci,L., Ostan,R., Monti,D., Biagi,E., Brigidi,P., Franceschi,C., Rezzi,S.

PLoS.One. 2013/03, Volume 8, Number 3, e56564

posted on 2013/02

The predictive adaptive response: modeling the life-history evolution of the butterfly Bicyclus anynana in seasonal environments

van den Heuvel,J., Saastamoinen,M., Brakefield,P.M., Kirkwood,T.B., Zwaan,B.J., Shanley,D.P.

Am.Nat. 2013/02, Volume 181, Number 2, E28-E42

posted on 2013/02

Gene expression analysis of mTOR pathway: association with human longevity

Passtoors,W.M., Beekman,M., Deelen,J., van der Breggen,R., Maier,A.B., Guigas,B., Derhovanessian,E., van Heemst,D., de Craen,A.J., Gunn,D.A., Pawelec,G., Slagboom,P.E.

Aging Cell 2013/02, Volume 12, Number 1, 24-31

posted on 2013/02

Birthweight discordant female twins and their offspring: is the intergenerational influence on birthweight due to genes or environment?

Hogberg,L., Lundholm,C., Cnattingius,S., Oberg,S., Iliadou,A.N.

Hum.Reprod. 2013/02, Volume 28, Number 2, 480-487

posted on 2013/02

Epigenetics and aging

D'Aquila,P., Rose,G., Bellizzi,D., Passarino,G.

Maturitas 2013/02, Volume 74, Number 2, 130-136

posted on 2013/01/11

Cytomegalovirus-associated accumulation of late-differentiated CD4 T-cells correlates with poor humoral response to influenza vaccination

Derhovanessian,E., Theeten,H., Hahnel,K., Van Damme,P., Cools,N., Pawelec,G.

Vaccine 2013/01/11, Volume 31, Number 4, 685-690

posted on 2013/01

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers

Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A., Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T., Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L., McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N., Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M., de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D., Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M., Hayward,C., Aulchenko,Y., Campbell,H., Rudan,I.

PLoS.Genet. 2013/01, Volume 9, Number 1, e1003225-

posted on 2013/01

Footprints of selection in wild populations of Bicyclus anynana along a latitudinal cline

de Jong,M.A., Collins,S., Beldade,P., Brakefield,P.M., Zwaan,B.J.

Mol.Ecol. 2013/01, Volume 22, Number 2, 341-353


IDEAL dissertations

Lovisa Högberg (5th of October 2012) Prenatal influences on health outcomes over the lifespan: Effects of smoking, socio-economic status and foetal growth. Karolinska Insititute

Vicencio Oostra (26th of June 2013) Hormonal and transcriptional mechanisms underlying developmental plasticity of life histories in a seasonal butterfly. Leiden University

Oluwatosin O. Taiwo (2013) The Role of DNA Methylation in Stem Cell Ageing. University college London

Alexis Grimaldi (16th of May 2014) Crosstalk between thyroid hormones and glucocrticoids during Xenopus tropicalis metamorphosis. Le Centre national de la recherche scientifique

Joris Deelen (25th of June 2014) Genetic and biomarker studies of human longevity. Leiden University Medical Center

Marianne Nygaard (8th of July 2014) Genetic Determinants of Healthy Aging – Studies of genetic variation associated with human longevity . Southern Denmark University

Joost van de Heuvel (25th of November 2014) The evolution and plasticity of life histories upon variation in nutrition : an ageing focused integrative approach. Leiden University

Erik B. van den Akker (18th of February 2015) Computational biology in human aging. An omics data integration approach. Leiden University Medical Center

Linda Ahrenfeldt (15th of Oktober 2015) Opposite-sex vs same-sex twins: mortality, cancer and behavior. Southern Denmark University

Fenni Rusli (29th of August 2016) Diet-induced phenotypic plasticity during aging. Wageningen University.  

Book Publications

Non-Genetic Inheritance. Tobias Uller and Heikki Helanterä. Volume 1, September 2013, Pages 27-32, ISSN (Online) 2084-8846, DOI:10.2478/ng-2013-0003.

Immunosenescence: Psychosocial and Behavioral Determinants. Jos A. Bosch, Anna C. Phillips, Anna C., Janet Lord (Eds.) 2013. Gramham Pawelec and Ludmilla Müller. Introduction to Ageing of the Adaptive Immune System. Chapter 2, pp 17-32.  DOI: 10.1007/978-1-4614-4776-4_2

The Philosophy of Biology: A companion for Educators. K.Kampouakis (ed.) History, Philosophy and Theory of the Life Sciences; Volume 1, 2013. Tobias Uller. Non-Genetic Inheritance and Evolution, pp 267-287.  DOI: 10.1007/978-94-007-6537-5_14.


See what we’re working on at the moment!



Meet the participants within IDEAL

Participants Participants

Impact on society

Check our contact with media

Impact on society Impact on society