Integrated research on Developmental determinants of Ageing and Longevity


or filter by or
posted on 2013/05

Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis

Bay-Jensen,A.C., Slagboom,E., Chen-An,P., Alexandersen,P., Qvist,P., Christiansen,C., Meulenbelt,I., Karsdal,M.A.

Menopause 2013/05, Volume 20, Number 5, 578-586

posted on 2013/04/05

Developmental neuroinflammation and schizophrenia

Prog.Neuropsychopharmacol.Biol.Psychiatry 2013/04/05, Volume 42, Number , 20-34

posted on 2013/04

Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans

Montesanto,A., Crocco,P., Tallaro,F., Pisani,F., Mazzei,B., Mari,V., Corsonello,A., Lattanzio,F., Passarino,G., Rose,G.

Biogerontology. 2013/04, Volume 14, Number 2, 177-186

posted on 2013/04

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

Deelen,J., Beekman,M., Capri,M., Franceschi,C., Slagboom,P.E.

Bioessays 2013/04, Volume 35, Number 4, 386-396

posted on 2013/04

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Beekman,M., Blanche,H., Perola,M., Hervonen,A., Bezrukov,V., Sikora,E., Flachsbart,F., Christiansen,L., de Craen,A.J., Kirkwood,T.B., Rea,I.M., Poulain,M., Robine,J.M., Valensin,S., Stazi,M.A., Passarino,G., Deiana,L., Gonos,E.S., Paternoster,L., Sorensen,T.I., Tan,Q., Helmer,Q., van den Akker,E.B., Deelen,J., Martella,F., Cordell,H.J., Ayers,K.L., Vaupel,J.W., Tornwall,O., Johnson,T.E., Schreiber,S., Lathrop,M., Skytthe,A., Westendorp,R.G., Christensen,K., Gampe,J., Nebel,A., Houwing-Duistermaat,J.J., Slagboom,P.E., Franceschi,C.

Aging Cell 2013/04, Volume 12, Number 2, 184-193

posted on 2013/04

Identification of seven loci affecting mean telomere length and their association with disease

Codd,V., Nelson,C.P., Albrecht,E., Mangino,M., Deelen,J., Buxton,J.L., Hottenga,J.J., Fischer,K., Esko,T., Surakka,I., Broer,L., Nyholt,D.R., Mateo,Leach,I, Salo,P., Hagg,S., Matthews,M.K., Palmen,J., Norata,G.D., O'Reilly,P.F., Saleheen,D., Amin,N., Balmforth,A.J., Beekman,M., de Boer,R.A., Böhringer,S., Braund,P.S., Burton,P.R., de Craen,A.J., Denniff,M., Dong,Y., Douroudis,K., Dubinina,E., Eriksson,J.G., Garlaschelli,K., Guo,D., Hartikainen,A.L., Henders,A.K., Houwing-Duistermaat,J.J., Kananen,L., Karssen,L.C., Kettunen,J., Klopp,N., Lagou,V., van Leeuwen,E.M., Madden,P.A., Magi,R., Magnusson,P.K., Mannisto,S., McCarthy,M.I., Medland,S.E., Mihailov,E., Montgomery,G.W., Oostra,B.A., Palotie,A., Peters,A., Pollard,H., Pouta,A., Prokopenko,I., Ripatti,S., Salomaa,V., Suchiman,H.E., Valdes,A.M., Verweij,N., Vinuela,A., Wang,X., Wichmann,H.E., Widen,E., Willemsen,G., Wright,M.J., Xia,K., Xiao,X., van Veldhuisen,D.J., Catapano,A.L., Tobin,M.D., Hall,A.S., Blakemore,A.I., van Gilst,W.H., Zhu,H., Consortium,C., Erdmann,J., Reilly,M.P., Kathiresan,S., Schunkert,H., Talmud,P.J., Pedersen,N.L., Perola,M., Ouwehand,W., Kaprio,J., Martin,N.G., van Duijn,C.M., Hovatta,I., Gieger,C., Metspalu,A., Boomsma,D.I., Jarvelin,M.R., Slagboom,P.E., Thompson,J.R., Spector,T.D., van der Harst,P., Samani,N.J.

Nat.Genet. 2013/04, Volume 45, Number 4, 422-422

posted on 2013/04

Oxidative stress and the ageing endocrine system

Vitale,G., Salvioli,S., Franceschi,C.

Nat.Rev.Endocrinol. 2013/04, Volume 9, Number 4, 228-240

posted on 2013/04

Association study of candidate genes for the progression of hand osteoarthritis

Bijsterbosch,J., Kloppenburg,M., Reijnierse,M., Rosendaal,F.R., Huizinga,T.W., Slagboom,P.E., Meulenbelt,I.

Osteoarthritis.Cartilage. 2013/04, Volume 21, Number 4, 565-569

posted on 2013/03/28

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

Cabreiro,F., Au,C., Leung,K.Y., Vergara-Irigaray,N., Cocheme,H.M., Noori,T., Weinkove,D., Schuster,E., Greene,N.D., Gems,D.

Cell 2013/03/28, Volume 153, Number 1, 228-239

posted on 2013/03/15

Maternal and fetal genetic contributions to postterm birth: familial clustering in a population-based sample of 475,429 Swedish births

Oberg,A.S., Frisell,T., Svensson,A.C., Iliadou,A.N.

Am.J.Epidemiol. 2013/03/15, Volume 177, Number 6, 531-537


IDEAL dissertations

Lovisa Högberg (5th of October 2012) Prenatal influences on health outcomes over the lifespan: Effects of smoking, socio-economic status and foetal growth. Karolinska Insititute

Vicencio Oostra (26th of June 2013) Hormonal and transcriptional mechanisms underlying developmental plasticity of life histories in a seasonal butterfly. Leiden University

Oluwatosin O. Taiwo (2013) The Role of DNA Methylation in Stem Cell Ageing. University college London

Alexis Grimaldi (16th of May 2014) Crosstalk between thyroid hormones and glucocrticoids during Xenopus tropicalis metamorphosis. Le Centre national de la recherche scientifique

Joris Deelen (25th of June 2014) Genetic and biomarker studies of human longevity. Leiden University Medical Center

Marianne Nygaard (8th of July 2014) Genetic Determinants of Healthy Aging – Studies of genetic variation associated with human longevity . Southern Denmark University

Joost van de Heuvel (25th of November 2014) The evolution and plasticity of life histories upon variation in nutrition : an ageing focused integrative approach. Leiden University

Erik B. van den Akker (18th of February 2015) Computational biology in human aging. An omics data integration approach. Leiden University Medical Center

Linda Ahrenfeldt (15th of Oktober 2015) Opposite-sex vs same-sex twins: mortality, cancer and behavior. Southern Denmark University

Fenni Rusli (29th of August 2016) Diet-induced phenotypic plasticity during aging. Wageningen University.  

Book Publications

Non-Genetic Inheritance. Tobias Uller and Heikki Helanterä. Volume 1, September 2013, Pages 27-32, ISSN (Online) 2084-8846, DOI:10.2478/ng-2013-0003.

Immunosenescence: Psychosocial and Behavioral Determinants. Jos A. Bosch, Anna C. Phillips, Anna C., Janet Lord (Eds.) 2013. Gramham Pawelec and Ludmilla Müller. Introduction to Ageing of the Adaptive Immune System. Chapter 2, pp 17-32.  DOI: 10.1007/978-1-4614-4776-4_2

The Philosophy of Biology: A companion for Educators. K.Kampouakis (ed.) History, Philosophy and Theory of the Life Sciences; Volume 1, 2013. Tobias Uller. Non-Genetic Inheritance and Evolution, pp 267-287.  DOI: 10.1007/978-94-007-6537-5_14.


See what we’re working on at the moment!



Meet the participants within IDEAL

Participants Participants

Impact on society

Check our contact with media

Impact on society Impact on society