Integrated research on Developmental determinants of Ageing and Longevity


or filter by or
posted on 2015/06

Accelerated epigenetic aging in Down syndrome

Horvath,S., Garagnani,P., Bacalini,M.G., Pirazzini,C., Salvioli,S., Gentilini,D., Di Blasio,A.M., Giuliani,C., Tung,S., Vinters,H.V., Franceschi,C.

Aging Cell 2015/06, Volume 14, Number 3, 491-495

posted on 2015/02

Identification of a DNA methylation signature in blood cells from persons with Down Syndrome

Bacalini,M.G., Gentilini,D., Boattini,A., Giampieri,E., Pirazzini,C., Giuliani,C., Fontanesi,E., Scurti,M., Remondini,D., Capri,M., Cocchi,G., Ghezzo,A., Del Rio,A., Luiselli,D., Vitale,G., Mari,D., Castellani,G., Fraga,M., Di Blasio,A.M., Salvioli,S., Franceschi,C., Garagnani,P.

Aging (Albany.NY) 2015/02, Volume 7, Number 2, 82-96

posted on 2014/08

mtDNA mutations in human aging and longevity: controversies and new perspectives opened by high-throughput technologies

Sevini,F., Giuliani,C., Vianello,D., Giampieri,E., Santoro,A., Biondi,F., Garagnani,P., Passarino,G., Luiselli,D., Capri,M., Franceschi,C., Salvioli,S.

Exp.Gerontol. 2014/08, Volume 56, Number , 234-244

posted on 2014/01/02

Present and future of anti-ageing epigenetic diets

Bacalini,M.G., Friso,S., Olivieri,F., Pirazzini,C., Giuliani,C., Capri,M., Santoro,A., Franceschi,C., Garagnani,P.

Mech.Ageing Dev. 2014/01/02, Volume , Number , -

posted on 2014

The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms

Garagnani,P., Pirazzini,C., Giuliani,C., Candela,M., Brigidi,P., Sevini,F., Luiselli,D., Bacalini,M.G., Salvioli,S., Capri,M., Monti,D., Mari,D., Collino,S., Delledonne,M., Descombes,P., Franceschi,C.

Biomed.Res.Int. 2014, Volume 2014, Number , 560340-

posted on 2014

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

Bacalini,M.G., Pacilli,A., Giuliani,C., Penzo,M., Trere,D., Pirazzini,C., Salvioli,S., Franceschi,C., Montanaro,L., Garagnani,P.

BMC.Cancer 2014, Volume 14, Number , 361-

posted on 2013/06

Immune system, cell senescence, aging and longevity--inflamm-aging reappraised

Salvioli,S., Monti,D., Lanzarini,C., Conte,M., Pirazzini,C., Bacalini,M.G., Garagnani,P., Giuliani,C., Fontanesi,E., Ostan,R., Bucci,L., Sevini,F., Yani,S.L., Barbieri,A., Lomartire,L., Borelli,V., Vianello,D., Bellavista,E., Martucci,M., Cevenini,E., Pini,E., Scurti,M., Biondi,F., Santoro,A., Capri,M., Franceschi,C.

Curr.Pharm.Des 2013/06, Volume 19, Number 9, 1675-1679

posted on 2013/05

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: a proof of principle on type 2 diabetes

Garagnani,P., Giuliani,C., Pirazzini,C., Olivieri,F., Bacalini,M.G., Ostan,R., Mari,D., Passarino,G., Monti,D., Bonfigli,A.R., Boemi,M., Ceriello,A., Genovese,S., Sevini,F., Luiselli,D., Tieri,P., Capri,M., Salvioli,S., Vijg,J., Suh,Y., Delledonne,M., Testa,R., Franceschi,C.

Aging (Albany.NY) 2013/05, Volume 5, Number 5, 373-385

posted on 2012/12

Methylation of ELOVL2 gene as a new epigenetic marker of age

Garagnani,P., Bacalini,M.G., Pirazzini,C., Gori,D., Giuliani,C., Mari,D., Di Blasio,A.M., Gentilini,D., Vitale,G., Collino,S., Rezzi,S., Castellani,G., Capri,M., Salvioli,S., Franceschi,C.

Aging Cell 2012/12, Volume 11, Number 6, 1132-1134

posted on 2012/07

Space/population and time/age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age

Pirazzini,C., Giuliani,C., Bacalini,M.G., Boattini,A., Capri,M., Fontanesi,E., Marasco,E., Mantovani,V., Pierini,M., Pini,E., Luiselli,D., Franceschi,C., Garagnani,P.

Aging (Albany.NY) 2012/07, Volume 4, Number 7, 509-520


IDEAL dissertations

Lovisa Högberg (5th of October 2012) Prenatal influences on health outcomes over the lifespan: Effects of smoking, socio-economic status and foetal growth. Karolinska Insititute

Vicencio Oostra (26th of June 2013) Hormonal and transcriptional mechanisms underlying developmental plasticity of life histories in a seasonal butterfly. Leiden University

Oluwatosin O. Taiwo (2013) The Role of DNA Methylation in Stem Cell Ageing. University college London

Alexis Grimaldi (16th of May 2014) Crosstalk between thyroid hormones and glucocrticoids during Xenopus tropicalis metamorphosis. Le Centre national de la recherche scientifique

Joris Deelen (25th of June 2014) Genetic and biomarker studies of human longevity. Leiden University Medical Center

Marianne Nygaard (8th of July 2014) Genetic Determinants of Healthy Aging – Studies of genetic variation associated with human longevity . Southern Denmark University

Joost van de Heuvel (25th of November 2014) The evolution and plasticity of life histories upon variation in nutrition : an ageing focused integrative approach. Leiden University

Erik B. van den Akker (18th of February 2015) Computational biology in human aging. An omics data integration approach. Leiden University Medical Center

Linda Ahrenfeldt (15th of Oktober 2015) Opposite-sex vs same-sex twins: mortality, cancer and behavior. Southern Denmark University

Fenni Rusli (29th of August 2016) Diet-induced phenotypic plasticity during aging. Wageningen University.  

Book Publications

Non-Genetic Inheritance. Tobias Uller and Heikki Helanterä. Volume 1, September 2013, Pages 27-32, ISSN (Online) 2084-8846, DOI:10.2478/ng-2013-0003.

Immunosenescence: Psychosocial and Behavioral Determinants. Jos A. Bosch, Anna C. Phillips, Anna C., Janet Lord (Eds.) 2013. Gramham Pawelec and Ludmilla Müller. Introduction to Ageing of the Adaptive Immune System. Chapter 2, pp 17-32.  DOI: 10.1007/978-1-4614-4776-4_2

The Philosophy of Biology: A companion for Educators. K.Kampouakis (ed.) History, Philosophy and Theory of the Life Sciences; Volume 1, 2013. Tobias Uller. Non-Genetic Inheritance and Evolution, pp 267-287.  DOI: 10.1007/978-94-007-6537-5_14.


See what we’re working on at the moment!



Meet the participants within IDEAL

Participants Participants

Impact on society

Check our contact with media

Impact on society Impact on society